Their results suggest that the youngest children from the most vulnerable populations benefit most and show significant improvements toward expected growth for their age and sex, particularly for weight.
A team of researchers from McGill, the University of British Columbia and others, set out to determine whether antibiotics lead to improvements in growth in pre-pubertal children living in low and middle income countries.
Paper's first author Ethan Gough, McGill PhD candidate in the Faculty of Medicine (Department of Epidemiology, Biostatistics and Occupational Health), said they looked at changes in both height and weight.
He said that they searched the research literature for studies that treated children aged 1 month to 12 years with an antibiotic, and analyzed the results of 10 trials involving 4,316 children in seven low and middle income countries. Children were generally smaller in height and weight than adequately nourished children of the same age. This group of studies reflects the spectrum of stunting and wasting malnutrition seen in these countries.
Amee Manges, a professor in the School of Population and Public Health, at the University of British Columbia, said that overall they we found that antibiotic treatment had a positive effect on both height and weight with increases of 0.04 cm/month for height and by 23.8 g/month for weight, asserting that after accounting for differences in the age of the study participants, effects on height were larger in the youngest children and effects on weight were larger in the trials that were conducted in Africa.
The results have been published in the British Medical Journal.
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